Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles

Authors :: Pascal Marchand
Patrice Le Pape
Guillaume Le Baut
Fabrice Pagniez
Marc Le Borgne
Young Min Na
Hiam Abdala
Cibles et médicaments de l'infection, de l'immunité et du cancer (IICiMed)
Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques
Université de Nantes (UN)-Université de Nantes (UN)
Source :: Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2002, 17 (6), pp.353-358. ⟨10.1080/1475636021000005613⟩
Publication Year :: 2002
Publisher :: HAL CCSD, 2002.
Abstract: The goal of the present study was to evaluate several azolyl-substituted indoles as new antileishmanial agents. Ten 3- (α -azolylbenzyl)indoles have been synthesized using Friedel-Crafts acylation as a key-step. All the target compounds were found to display high levels of activity when tested against Leishmania mexicana promastigotes in vitro. The most active compounds, showing an IC 50

Language :: English
ISSN :: 14756366 and 14756374
Database :: OpenAIRE
Journal :: Journal of Enzyme Inhibition and Medicinal Chemistry, Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2002, 17 (6), pp.353-358. ⟨10.1080/1475636021000005613⟩
Accession number :: edsair.doi.dedup.....6f2330ca733cd963e192c83b011cd5c5
Full Text :: https://doi.org/10.1080/1475636021000005613⟩