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BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis
- Source :
- Sci Transl Med, Brook, B, Harbeson, D J, Shannon, C P, Cai, B, He, D, Ben-Othman, R, Francis, F, Huang, J, Varankovich, N, Liu, A, Bao, W, Bjerregaard-Andersen, M, Schaltz-Buchholzer, F, Sanca, L, Golding, C N, Larsen, K L, Levy, O, Kampmann, B, EPIC Consortium, Tan, R, Charles, A, Wynn, J L, Shann, F, Aaby, P, Benn, C S, Tebbutt, S J, Kollmann, T R & Amenyogbe, N 2020, ' BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis ', Science Translational Medicine, vol. 12, no. 542, eaax4517 . https://doi.org/10.1126/scitranslmed.aax4517
- Publication Year :
- 2020
- Publisher :
- American Association for the Advancement of Science (AAAS), 2020.
-
Abstract
- Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration. This was necessary and sufficient to drive emergency granulopoiesis (EG), resulting in a marked increase in neutrophils. This increase in neutrophils was directly and quantitatively responsible for protection from sepsis. Rapid induction of EG after BCG administration also occurred in three independent cohorts of human neonates.
- Subjects :
- Neonatal sepsis
business.industry
Vaccination
Infant, Newborn
General Medicine
Granulocyte
medicine.disease
Systemic inflammation
Granulopoiesis
Article
Hematopoiesis
Granulocyte colony-stimulating factor
Sepsis
medicine.anatomical_structure
Granulocyte Colony-Stimulating Factor
Immunology
medicine
Humans
Tumor necrosis factor alpha
Neonatal Sepsis
medicine.symptom
business
Subjects
Details
- ISSN :
- 19466242 and 19466234
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Science Translational Medicine
- Accession number :
- edsair.doi.dedup.....6f38c238ac90eb56bae1dad1e2ccfe0a