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Primary nasal-ethmoid choriocarcinoma detected by 18F-FDG PET/CT: a rare tumor with complete remission
- Source :
- Nuclear Medicine Review. 23:105-107
- Publication Year :
- 2020
- Publisher :
- VM Media SP. zo.o VM Group SK, 2020.
-
Abstract
- Choriocarcinoma is a highly malignant and rare tumor characterized by secretion of the beta-subunit-of-humanchoriogonadotropin (β-HCG). We report a case of primary nasal choriocarcinoma with good response to chemotherapy. A 36-years-old woman gravida 0 and with history of 4 spontaneous abortion, in December 2018 referred to Otorhinolaryngology Department for repeated episodes of epistaxis. Cervical Magnetic Resonance Imaging (MRI) revealed a tumor mass involving right nasal cavity, right ethmoid, sphenoidal and maxillary sinuses. For a differential diagnosis between metastatic gestational choriocarcinoma and primary choriocarcinoma in January 2019 she underwent 18Fluorine-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) scan that demonstrated intense uptake only in the nasal-ethmoid tumor mass showed by MRI. This was suggestive of primary nasal-ethmoid choriocarcinoma she received 3 courses of BEP - regimen and after β-HCG was reduced to 500 mIU/mL and 18F-FDG-PET/CT scan showed a decreased uptake in tumor mass but the appearance of a new uptake in cervical lymph node which was analysed and reported as metastatic localization of choriocarcinoma. Therefore she was treated with 2 cycles of TIP-regimen. Subsequents 18F-FDG-PET/CT and MRI showed a complete tumor remission. This case proved the fundamental role of PET/CT to make diagnosis of primitive choriocarcinoma and to exclude the hypothesis of distant metastasis.
- Subjects :
- Adult
medicine.medical_specialty
PET/CT
medicine.medical_treatment
Nose Neoplasms
Gestational choriocarcinoma
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
choriocarcinoma
medicine
Humans
nasal-ethmoidal
Radiology, Nuclear Medicine and imaging
Lymph node
reproductive and urinary physiology
Chemotherapy
PET-CT
medicine.diagnostic_test
business.industry
Choriocarcinoma
Magnetic resonance imaging
General Medicine
medicine.disease
Treatment Outcome
medicine.anatomical_structure
Positron emission tomography
embryonic structures
Female
Radiology
Differential diagnosis
business
Subjects
Details
- ISSN :
- 16444345 and 15069680
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Review
- Accession number :
- edsair.doi.dedup.....6f402acba7706dd2d42203fc61d86c0e