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Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies
- Source :
- Frontiers in Oncology, Vol 11 (2021), Frontiers in Oncology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. However, small molecule inhibitors targeting ROR1 are underappreciated because of the initial characterization of ROR1 as a peusdokinase. The function of ROR1 as a tyrosine kinase remains poorly understood, although accumulating evidence have demonstrated its intrinsic tyrosine kinase activity. In this review, we analyzed the structural and functional features of ROR1 and discussed therapeutic strategies targeting this kinase.
- Subjects :
- Cancer Research
kinase function
biology
Kinase
medicine.medical_treatment
Wnt signaling pathway
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Review
kinase activity
medicine.disease_cause
targeted therapy
small molecule inhibitors
Receptor tyrosine kinase
Targeted therapy
Oncology
ROR1
biology.protein
medicine
Cancer research
Kinase activity
Carcinogenesis
Tyrosine kinase
RC254-282
Subjects
Details
- Language :
- English
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....6f453d4b427d57460d3b4b31fe3cfa59