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Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies

Authors :
Yao Guo
Dengyang Zhang
Xiaojun Xu
Yun Chen
Zhizhuang Joe Zhao
Yuming Zhao
Bo Lu
Source :
Frontiers in Oncology, Vol 11 (2021), Frontiers in Oncology
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. However, small molecule inhibitors targeting ROR1 are underappreciated because of the initial characterization of ROR1 as a peusdokinase. The function of ROR1 as a tyrosine kinase remains poorly understood, although accumulating evidence have demonstrated its intrinsic tyrosine kinase activity. In this review, we analyzed the structural and functional features of ROR1 and discussed therapeutic strategies targeting this kinase.

Details

Language :
English
Volume :
11
Database :
OpenAIRE
Journal :
Frontiers in Oncology
Accession number :
edsair.doi.dedup.....6f453d4b427d57460d3b4b31fe3cfa59