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Interleukin IL-5 alleviates sepsis-induced acute lung injury by regulating the immune response in rats
- Source :
- Bioengineered, Vol 12, Iss 1, Pp 2132-2139 (2021), Bioengineered, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- To study the effect of IL-5 on the immune response and lung injury in rats with sepsis. We constructed a rat model of sepsis by cecal ligation and puncture (CLP). The rats were randomly divided into the control group, the sham group, the CLP group and the IL-5 group, with 6 rats in each group. With the induction of CLP, the lung tissue of rats was severely injured, and the water content of lung tissue was significantly increased. Moreover, the ratio of CD4+/CD8+ was significantly decreased and Th1/Th2 was significantly increased in the peripheral blood. The content of IL-6, TNF-α, and HMGB1 was found to be increased in the CLP group. However, with the injection of IL-5, the degree of lung tissue injury in CLP rats was alleviated and the water content of lung tissue was significantly reduced. The ratio of CD4+/CD8+ was increased and Th1/Th2 was significantly down-regulated in the peripheral blood and the levels of IL-6, TNF-α, and HMGB1 in serum were significantly decreased. In conclusion, IL-5 can alleviate lung injury by regulating the immune response and inhibiting the systemic inflammatory response induced by sepsis.<br />Graphical abstract
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Bioengineering
Lung injury
HMGB1
Applied Microbiology and Biotechnology
immune response
Sepsis
Rats, Sprague-Dawley
sepsis
03 medical and health sciences
0302 clinical medicine
Immune system
Internal medicine
medicine
il-5
Animals
Interleukin 5
Lung
biology
business.industry
Interleukin
General Medicine
medicine.disease
Peripheral blood
Rats
Disease Models, Animal
030104 developmental biology
Endocrinology
acute lung injury
030220 oncology & carcinogenesis
biology.protein
Cytokines
Interleukin-5
business
CD8
TP248.13-248.65
Research Article
Research Paper
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 21655987 and 21655979
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Bioengineered
- Accession number :
- edsair.doi.dedup.....6f548e6d490cd9dfa778463f56bdef64