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Development of Simvastatin Loaded Electrospun Zein Nanofiber Membranes for Bone Repair
- Source :
- Journal of Nanoscience and Nanotechnology. 21:5099-5106
- Publication Year :
- 2021
- Publisher :
- American Scientific Publishers, 2021.
-
Abstract
- The present study aims to prepare and And Characterization of zein nanofibers with simvastatin-loaded in it by electrospinning method using a polymeric matrix prepared from zein solution containing simvastatin antibiotics. The physical, cellular properties and drug release kinetics of the fibers were studied. Fiber formation was investigated by implementing a scanning electron microscope (SEM). The SEM images show a uniform network bead-free fiber structure created from the 1.5% simvastatin/zeinsolution. The viscosity of the 1.5% simvastatin/zein mixture increased to 0.402 P due to the presence of drug in zein solution. Also, the presence of the indicative peaks associated with simvastatin in the Fourier transform infrared (FTIR) spectra of the samples containing the drug, verifies the existence of the drug on the polymeric base of zein/polyethylene oxide (PEO). Also, around 53.887% of the loaded drug was released in the first 12 h of the release kinetics assay and the results of the MTT assay shows reduction in the number of live cells in the test sample. In conclusion, zein nanofibers containing simvastatin drug were found to be potential biodegradable polymers that can find application in bone tissue repair.
- Subjects :
- Simvastatin
Materials science
Zein
Nanofibers
Biomedical Engineering
Bioengineering
02 engineering and technology
Bone tissue
Bone and Bones
Mice
Spectroscopy, Fourier Transform Infrared
medicine
Animals
General Materials Science
Fiber
Fourier transform infrared spectroscopy
Cells, Cultured
Viscosity
food and beverages
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Biodegradable polymer
Electrospinning
Drug Liberation
medicine.anatomical_structure
Membrane
Chemical engineering
Nanofiber
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 15334880
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Nanoscience and Nanotechnology
- Accession number :
- edsair.doi.dedup.....6f54f69cf5f51d03a85ee5d8859880dd