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Immunoglobulin levels during follow-up of children with selective IgA deficiency
- Source :
- Scandinavian journal of immunology. 35(6)
- Publication Year :
- 1992
-
Abstract
- Longitudinal serum immunoglobulin levels were studied in 36 children with selective IgA deficiency during a median follow-up period of 5 years. Twenty-live children were "sporadic' cases, and 11 were "familiar. Serum and saliva IgA levels in 23 children remained below 2 mg/'l. Eight children with IgA levels above 2 mg/1 showed considerahle intra-individual variance in serum IgA. but remained IgA deficient. Five children at various ages developed IgA levels above 50mg/l with detectable secretory IgA in saliva- In most of the children IgG subclass levels were found to be rather high, including at younger ages. There were no obvious differences between 'sporadie' and 'familial' eases except an assoeiation between IgD deficiency and serum IgA levels below 2 mg/1, and between serum levels of IgD above 1 ItJ/ml and of IgA above 2 mg/1, which was found to be significant in the "sporadic' group but not in the "familial' group.
- Subjects :
- Male
Saliva
Immunoglobulin levels
Adolescent
Immunology
Immunoglobulins
Selective IgA deficiency
Immunoglobulin E
Immunoglobulin D
Subclass
medicine
Humans
Longitudinal Studies
Child
biology
business.industry
IgA Deficiency
Infant
General Medicine
medicine.disease
Immunoglobulin A
El Niño
Immunoglobulin M
Child, Preschool
Immunoglobulin G
Immunoglobulin A, Secretory
biology.protein
Female
Dysgammaglobulinemia
Antibody
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 03009475
- Volume :
- 35
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of immunology
- Accession number :
- edsair.doi.dedup.....6f73fbb5784cd6c12485c5e741fd5f9d