Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated with Reduced NT-proANP, Increased Stroke and Higher Diastolic Blood Pressure

Authors :: Gregory D. Jenkins
Naresh Prodduturi
John C. Burnett
Christopher G. Scott
Richard M. Weinshilboum
Richard J. Rodeheffer
Nirubol Tosakulwong
Yubo Chai
Naveen L. Pereira
Margaret M. Redfield
Timothy M. Olson
Source :: BMC Pharmacology & Toxicology
Publication Year :: 2015
Publisher :: Springer Science and Business Media LLC, 2015.
Abstract: The goal of this study was to identify genetic determinants of plasma N-terminal proatrial natriuretic peptide (NT-proANP) in the general community by performing a large-scale genetic association study and to assess its functional significance in in vitro cell studies and on disease susceptibility.

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