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The role of IL-1β in aortic aneurysm
- Source :
- Clinica Chimica Acta. 504:7-14
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Interleukin-1β (IL-1β) is a vital cytokine that plays an important role in regulating immune responses to infectious challenges and sterile insults. In addition, two endogenous inhibitors of functional receptor binding, IL-1 receptor antagonist (IL-1Ra), complete the family. To gain biological activity, IL-1β requires processing by the protease caspase-1 and activation of inflammasomes. Numerous clinical association studies and experimental approaches have implicated members of the IL-1 family, their receptors, or components of the processing machinery in the underlying processes of cardiovascular diseases. Here, we summarize the current state of knowledge regarding the pro-inflammatory and disease-modulating role of the IL-1 family in aneurysm. We discuss clinical evidence, signalling pathway, and mechanism of action and last, lend a perspective on currently developing therapeutic strategies involving IL-1β in aneurysm.
- Subjects :
- 0301 basic medicine
Inflammasomes
medicine.drug_class
medicine.medical_treatment
Interleukin-1beta
Clinical Biochemistry
Inflammation
Bioinformatics
Biochemistry
03 medical and health sciences
Aortic aneurysm
0302 clinical medicine
Immune system
medicine
Humans
Receptor
business.industry
Caspase 1
Biochemistry (medical)
General Medicine
medicine.disease
Receptor antagonist
Hedgehog signaling pathway
Aortic Aneurysm
030104 developmental biology
Cytokine
Mechanism of action
030220 oncology & carcinogenesis
Cytokines
medicine.symptom
business
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 504
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....6f831075553e6234857eca837a3ecc4b