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The anti-inflammatory activity of peptides from simulated gastrointestinal digestion of preserved egg white in DSS-induced mouse colitis
- Source :
- Food & Function. 9:6444-6454
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry (RSC), 2018.
-
Abstract
- Peptides DEDTQAMPFR (DR-10), MLGATSL (ML-7), SLSFASR (SR-7), and MSYSAGF (MF-7) derived from simulated gastrointestinal digestion of preserved egg white (SGD-PEW) exerted anti-inflammatory effects on Caco-2 cells. Here, we aimed to evaluate the anti-inflammatory effects of these peptides derived from SGD-PEW in a mouse model of dextran sodium sulfate (DSS)-induced colitis. The results showed that DR-10, ML-7, SR-7 and MF-7 significantly ameliorated the clinical symptoms of DSS-induced mice colitis, such as weight loss, disease activity index (DAI), colon shortening, spleen hypertrophy and histological scores. Treatment with DR-10, ML-7, SR-7 and MF-7 also significantly inhibited the local secretion of pro-inflammatory cytokines TNF-α and IL-6 and markedly decreased the gene expression of pro-inflammatory cytokines, including TNF-α, IL-6, IL-17, IL-1β, IFN-γ and MCP-1, in DSS-induced mice colitis. Overall, MF-7 showed the best effect of alleviating DSS-induced colitis among the four peptides. These results suggested that MF-7, DR-10, ML-7 and SR-7 may be a potential promising candidate for the treatment of inflammatory bowel disease (IBD).
- Subjects :
- 0301 basic medicine
medicine.drug_class
Interleukin-1beta
Anti-Inflammatory Agents
Spleen
Pharmacology
Inflammatory bowel disease
Anti-inflammatory
Muscle hypertrophy
Mice
03 medical and health sciences
0302 clinical medicine
Egg White
Gene expression
medicine
Animals
Humans
Colitis
Ovum
Mice, Inbred BALB C
Tumor Necrosis Factor-alpha
business.industry
Dextran Sulfate
General Medicine
Inflammatory Bowel Diseases
medicine.disease
Disease Models, Animal
Ducks
030104 developmental biology
medicine.anatomical_structure
Cytokines
Digestion
Female
030211 gastroenterology & hepatology
Caco-2 Cells
Peptides
business
Food Science
Egg white
Subjects
Details
- ISSN :
- 2042650X and 20426496
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Food & Function
- Accession number :
- edsair.doi.dedup.....6f8b7a66d262fb398d739e7e88c90ee5