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HE4 as an Early Detection Biomarker of Epithelial Ovarian Cancer: Investigations in Prediagnostic Specimens From the Janus Serumbank
- Source :
- International Journal of Gynecologic Cancer. 25:1608-1615
- Publication Year :
- 2015
- Publisher :
- BMJ, 2015.
-
Abstract
- ObjectivesEpithelial ovarian cancer is characterized by nonspecific signs and clinical symptoms arising at late stages. Early detection is therefore important and may significantly improve the survival rate. Cancer antigen 125 (CA125) has been the most extensively studied serum biomarker in epithelial ovarian cancer, but low specificity limits its usefulness. A relatively novel biomarker, human epididymis protein 4 (HE4), has shown promise in early detection of the disease. The aim of this study was to investigate how early the tumor marker increases before diagnosis.Methods/MaterialsA nested case-control design was used to evaluate the performance of HE4 and CA125 in prediagnostic serum samples from the Janus Serumbank. Serial specimens from 120 women with invasive epithelial ovarian cancer were compared with healthy controls. Serum level of CA125, HE4, and cotinine was measured. Spearman correlation and multiple linear regression analyses were used to investigate impact of smoking, age, storage time, and lag time (time from sampling until date of diagnosis).ResultsSpearman correlation showed a strong positive correlation between HE4 and smoking in both cases and controls. Multiple linear regression analyses for pairwise differences between case and control showed that serum level of HE4 and CA125 was significantly increased (P= 0.002 andP< 0.001, respectively) 2 years before diagnosis and that CA125 also was significantly increased up to 4 years before diagnosis (P= 0.002).ConclusionsThe present study showed that a difference between cases and controls in serum concentration of HE4 seemed to be increased 2 years before diagnosis and that CA125 was increased until 4 years before diagnosis.
- Subjects :
- Oncology
medicine.medical_specialty
Pathology
Time Factors
Disease
Carcinoma, Ovarian Epithelial
chemistry.chemical_compound
WAP Four-Disulfide Core Domain Protein 2
Internal medicine
Carcinoma
Humans
Medicine
Neoplasms, Glandular and Epithelial
Cotinine
Survival rate
Early Detection of Cancer
Biological Specimen Banks
Tumor marker
Ovarian Neoplasms
Norway
business.industry
Smoking
Case-control study
Proteins
Obstetrics and Gynecology
Middle Aged
medicine.disease
chemistry
CA-125 Antigen
Case-Control Studies
Biomarker (medicine)
Female
business
Ovarian cancer
Subjects
Details
- ISSN :
- 15251438 and 1048891X
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecologic Cancer
- Accession number :
- edsair.doi.dedup.....6fae419c5494324e28a42da6dfac3e5c