Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis

Authors :: Yingying Ning
Iris Yuwen Zhou
Nicholas J. Rotile
Pamela Pantazopoulos
Huan Wang
Stephen Cole Barrett
Mozhdeh Sojoodi
Kenneth K. Tanabe
Peter Caravan
Source :: Journal of the American Chemical Society. 144(36)
Publication Year :: 2022
Abstract: Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde containing amino acid allysine (Lys

Subjects :: Manganese
Mice
Colloid and Surface Chemistry
Hydrazines
Liver
Animals
Contrast Media
General Chemistry
Biochemistry
Magnetic Resonance Imaging
Catalysis

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