Physical relationship between canine factor VIII coagulant activity and factor VIII-related antigen

SummaryTwo of three insolubilized anti-canine FVIII systems removed similar amounts of VIII-C and VIII-RA from canine plasma. These data suggest that VIII-C and VIII-RA form part of one circulating complex.The authors thank Dr. W. P. Webster, Chapel Hill, N.C., for providing the canine hemophilia A plasma and Joanne E. Kull for her assistance in collecting canine plasma samples and immunizing the rabbits.