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The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose

Authors :
Ansong Chen
Stephen Edge
John N. Staniforth
D. Fraser Steele
Mike Tobyn
Source :
International Journal of Pharmaceutics. 200:67-72
Publication Year :
2000
Publisher :
Elsevier BV, 2000.

Abstract

The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model.

Details

ISSN :
03785173
Volume :
200
Database :
OpenAIRE
Journal :
International Journal of Pharmaceutics
Accession number :
edsair.doi.dedup.....6ff513095f9589b59063aeb6f3ae18e9