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The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose
- Source :
- International Journal of Pharmaceutics. 200:67-72
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model.
- Subjects :
- Materials science
Silicon
Silicon dioxide
Chemistry, Pharmaceutical
Drug Compounding
Compaction
Pharmaceutical Science
Excipient
chemistry.chemical_element
Silicon Dioxide
Excipients
Microcrystalline cellulose
chemistry.chemical_compound
chemistry
Hardness
Tensile Strength
Lubrication
Ultimate tensile strength
medicine
Powders
Cellulose
Composite material
medicine.drug
Tensile testing
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 200
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....6ff513095f9589b59063aeb6f3ae18e9