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New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae)
- Source :
- Records of Natural Products, Vol 12, Iss 2, Pp 121-127 (2018)
- Publication Year :
- 2018
- Publisher :
- ACG Publications, 2018.
-
Abstract
- A new pregnane-type steroid, 2α-hydroxy-3α-methoxy-5α-pregnane (1), together with three known dammarane-type triterpenoid, 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (2), 20S,24S-epoxy-3α,25-dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structure s were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells .
- Subjects :
- medicine.medical_treatment
Aglaia elliptica
Plant Science
01 natural sciences
Steroid
lcsh:Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
lcsh:Botany
Drug Discovery
medicine
Cytotoxic T cell
Meliaceae
cytotoxic activity
Pharmacology
Stem bark
Traditional medicine
biology
010405 organic chemistry
Organic Chemistry
Pregnane
biology.organism_classification
Pregnane-type steroid
lcsh:QK1-989
0104 chemical sciences
010404 medicinal & biomolecular chemistry
lcsh:QD1-999
chemistry
Subjects
Details
- ISSN :
- 13076167
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Records of Natural Products
- Accession number :
- edsair.doi.dedup.....6ffc5950aad562ecf2bf8601e1599eb9
- Full Text :
- https://doi.org/10.25135/rnp.21.17.07.118