Supplementary Figures 1-6 from ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

PDF file - 296K, Figure S1: ICOS is mainly expressed by TA-Treg. Figure S2: pDC expanded Treg sustain suppressive activity. Figure S3: ICOS-L is highly expressed on R848-activated HD-pDC. Figure S4: ICOS blockade reduces Treg but not Tconv proliferation induced by pDC without impacting mDC/T cell activation. Figure S5: Strong IL-10 secretion in culture of BT single cell suspension. Figure S6: Correlation between TA-pDC and TA-Treg percentages in fresh primary BT and in retrospective IHC cohort