Back to Search
Start Over
Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin
Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin
- Source :
- Leukemia. 31:1079-1086
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- The origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However, a diagnostic approach to distinguish between cancers initiated pre- or postnatally is absent. Here we identified a transcriptional factor FEV (fifth Ewing variant) that was expressed in fetal hematopoietic cells and became silent after birth. We characterized that FEV was essential for the self-renewal of hematopoietic stem cells (HSCs). We next found that FEV was expressed in most infant leukemia samples, but seldom in adult samples, in accord with the known prenatal origins of the former. We further determined the majority of pediatric acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) were FEV positive. Moreover, FEV knockdown markedly impaired the leukemia-propagating ability of leukemic stem cells. We therefore identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin. It may also provide a tractable therapeutic target.
- Subjects :
- 0301 basic medicine
Cancer Research
Myeloid
Gene Expression
Mice
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Animals
Humans
Cells, Cultured
Gene knockdown
Fetus
Leukemia
business.industry
Nuclear Proteins
Myeloid leukemia
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic Stem Cells
medicine.disease
DNA-Binding Proteins
Fetal Diseases
Leukemia, Myeloid, Acute
Haematopoiesis
030104 developmental biology
medicine.anatomical_structure
Oncology
In utero
030220 oncology & carcinogenesis
Immunology
Heterografts
Female
Stem cell
business
Transcription Factors
Subjects
Details
- ISSN :
- 14765551 and 08876924
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Leukemia
- Accession number :
- edsair.doi.dedup.....700fe46b7613a8678e7faae0c554428e
- Full Text :
- https://doi.org/10.1038/leu.2016.313