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Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma
Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma
- Source :
- Journal of Pediatric Hematology/Oncology. 39:e443-e445
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Adolescent
Somatic cell
Biopsy
Sarcoma, Ewing
Article
Intracardiac injection
Heart Neoplasms
03 medical and health sciences
0302 clinical medicine
Germline mutation
Antineoplastic Combined Chemotherapy Protocols
Recurrent Ewing Sarcoma
Humans
Medicine
Digital polymerase chain reaction
medicine.diagnostic_test
business.industry
RNA-Binding Proteins
Neoplasms, Second Primary
Sarcoma
Hematology
medicine.disease
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Mutation
Pediatrics, Perinatology and Child Health
Calmodulin-Binding Proteins
Spindle cell sarcoma
RNA-Binding Protein EWS
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 10774114
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Hematology/Oncology
- Accession number :
- edsair.doi.dedup.....7024bbd1b6f6492198fe44521f107f9f
- Full Text :
- https://doi.org/10.1097/mph.0000000000000754