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Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma

Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma

Authors :
Meera Hameed
Emily K. Slotkin
Leonard H. Wexler
Alexander J. Chou
Anita P. Price
Paul A. Meyers
Alex Kentsis
Heather Magnan
Ahmet Zehir
Jennifer Kennedy
Michael V. Ortiz
Suzanne L. Wolden
Todd E. Heaton
Srikanth R. Ambati
Neerav Shukla
Michael F. Berger
Leonard N. Girardi
Michael Walsh
Source :
Journal of Pediatric Hematology/Oncology. 39:e443-e445
Publication Year :
2017
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2017.

Abstract

A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

Details

ISSN :
10774114
Volume :
39
Database :
OpenAIRE
Journal :
Journal of Pediatric Hematology/Oncology
Accession number :
edsair.doi.dedup.....7024bbd1b6f6492198fe44521f107f9f
Full Text :
https://doi.org/10.1097/mph.0000000000000754