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Treatment Outcomes with CHOP Chemotherapy in Adult Patients with Hemophagocytic Lymphohistiocytosis
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2008
- Publisher :
- The Korean Academy of Medical Sciences, 2008.
-
Abstract
- The objective of the current study was to investigate the treatment outcomes for the use of cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) chemotherapy in adult patients with hemophagocytic lymphohistiocytosis (HLH). Seventeen HLH patients older than 18 yr of age were treated with CHOP chemotherapy. A response evaluation was conducted for every two cycles of chemotherapy. With CHOP chemotherapy, complete response was achieved for 7/17 patients (41.2%), a partial response for 3/17 patients (17.6%), and the overall response rate was 58.8%. The median response duration (RD) was not reached and the 2-yr RD rate was 68.6%, with a median follow-up of 100 weeks. Median overall survival (OS) was 18 weeks (95% CI, 6-30 weeks) and the 2-yr OS rate was 43.9%. Reported grade 3 or 4 non-hematological toxicities were increased serum liver enzyme levels and stomatitis. Grade 3 or 4 hematological toxicities were leukopenia (50.8%), anemia (20%), and thrombocytopenia (33.9%). Neutropenic fever was observed in 21.6% of patients (14/65 cycles), and most of the cases were resolved with supportive care including treatment with broad-spectrum antibiotics. CHOP chemotherapy seems to be effective in adult HLH patients and the toxicities are manageable.
- Subjects :
- Adult
Male
medicine.medical_specialty
Vincristine
Herpesvirus 4, Human
Cyclophosphamide
Lymphoma
Adolescent
medicine.medical_treatment
CHOP
Gastroenterology
Lymphohistiocytosis, Hemophagocytic
CHOP Protocol
Internal medicine
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Survival rate
Aged
Hemophagocytic lymphohistiocytosis
Chemotherapy
Leukopenia
L-Lactate Dehydrogenase
business.industry
Remission Induction
General Medicine
Middle Aged
medicine.disease
Surgery
Survival Rate
Treatment Outcome
Doxorubicin
Prednisolone
Prednisone
Original Article
Female
medicine.symptom
business
medicine.drug
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....702a362bf1bacc68d4d55906627ca09d