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Effects of electrical stimulation of the striatum on bladder activity in cats
- Source :
- Neurourology and Urodynamics. 28:549-554
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Aims Parkinson's disease (PD) affects the nigrostriatal projections leading to micturition disturbance in most cases. Overactive bladder (OAB) symptoms such as urinary urgency or urgent urinary incontinence are common amongst PD patients. Several urodynamic studies have revealed that detrusor overactivity causes OAB symptoms in PD patients. We assert that striatal dysfunction might contribute to the pathogenesis of detrusor overactivity in PD patients. However, the role of the striatum in bladder contraction remains unclear. Methods We generated spontaneous isovolumetric bladder contractions in 12 ketamine-anesthetized adult male cats and subsequently performed electrical stimulation and extracellular single-unit recording in the striatum. Results Electrical stimulation applied to the posterior ventral caudate nucleus and the adjacent putamen educed inhibition of the spontaneous bladder contraction. None of the responses were facilitatory. Electrical stimulation was most effective at an amplitude of 70–400 µA. Forty-six neurons that exhibited correlation to spontaneous bladder contraction were recorded in the striatum. Thirty-five neurons were found to be tonically active throughout the bladder relaxation phase, and the remaining 11 neurons were active during the bladder contraction phase. These particular neurons were located within the area in which spontaneous bladder contraction was inhibited by electrical stimulation. Conclusions Electrical stimulation was found to inhibit bladder contraction, and a correlation was observed between spontaneous bladder relaxation/contraction and neuronal firing in the posterior ventral striatum. Neurourol. Urodyn. 28:549–554, 2009. © 2009 Wiley-Liss, Inc.
- Subjects :
- Male
medicine.medical_specialty
Urology
media_common.quotation_subject
Urinary Bladder
Caudate nucleus
Urination
Stimulation
Striatum
urologic and male genital diseases
Nerve Fibers
Neural Pathways
Basal ganglia
Pressure
medicine
Animals
Evoked Potentials
media_common
business.industry
Putamen
Ventral striatum
Muscle, Smooth
Neural Inhibition
medicine.disease
Electric Stimulation
female genital diseases and pregnancy complications
medicine.anatomical_structure
nervous system
Overactive bladder
Anesthesia
Cats
Neurology (clinical)
Caudate Nucleus
business
Muscle Contraction
Subjects
Details
- ISSN :
- 15206777 and 07332467
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Neurourology and Urodynamics
- Accession number :
- edsair.doi.dedup.....703e6f3422639f57c8a69381e438a34c