Hantavirus pulmonary syndrome outbreaks associated with climate variability in Northwestern Argentina, 1997-2017

Background Rodent-borne hantaviruses (genus Orthohantavirus) are the etiologic agents causing two human diseases: hemorrhagic fever with renal syndrome (HFRS) in Euroasia; and hantavirus pulmonary syndrome (HPS) in North and South America. In South America fatality rates of HPS can reach up to 35%–50%. The transmission of pathogenic hantaviruses to humans occurs mainly via inhalation of aerosolized excreta from infected rodents. Thus, the epidemiology of HPS is necessarily linked to the ecology of their rodent hosts and the contact with a human, which in turn may be influenced by climatic variability. Here we examined the relationship between climatic variables and hantavirus transmission aim to develop an early warning system of potential hantavirus outbreaks based on ecologically relevant climatic factors. Methodology and main findings We compiled reported HPS cases in northwestern Argentina during the 1997–2017 period and divided our data into biannual, quarterly, and bimestrial time periods to allow annual and shorter time delays to be observed. To evaluate the relationship of hantavirus transmission with mean temperature and precipitation we used dynamic regression analysis. We found a significant association between HPS incidence and lagged rainfall and temperature with a delay of 2 to 6 months. For the biannual and quarterly models, hantavirus transmission was positively associated with lagged rainfall and temperature; whereas the bimestrial models indicate a direct relationship with the rainfall but inverse for temperature in the second lagged period. Conclusions/Significance This work demonstrates that climate variability plays a significant role in the transmission of hantavirus in northwestern Argentina. The model developed in this study provides a basis for the forecast of potential HPS outbreaks based on climatic parameters. Our findings are valuable for the development of public health policies and prevention strategies to mitigate possible outbreaks. Nonetheless, a surveillance program on rodent population dynamics would lead to a more accurate forecast of HPS outbreaks.
Author summary Hantavirus pulmonary syndrome (HPS) is a Pan-American emerging disease with a high mortality rate caused by a rodent-borne virus. In Argentina, almost half of the HPS infections occur in the northwestern endemic region. Most of the reported cases (75%) developed severe respiratory insufficiency, of which 30% required mechanical ventilation and 15% with a fatal outcome. In this study area, nearly half of the population is below the poverty line, particularly in rural areas, where most infections occur. Since there are no vaccines currently available nor specific therapeutic treatments, prevention of hantavirus infection involves mainly environmental management practices and educational campaigns. Our results provide a framework for the planning and implementation of early public health prevention campaigns based on the significant relationship between hantavirus outbreaks and delayed climatic variables.