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The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle
- Source :
- Exercise and sport sciences reviews. 50(1)
- Publication Year :
- 2021
-
Abstract
- Inducible heme oxygenase (HO)-1 catalyzes the breakdown of heme to biliverdin, iron, and carbon monoxide (CO). CO binds to cytochrome c oxidase and alters mitochondrial redox balance and coordinately regulates mitochondrial quality control (MQC) during oxidant stress and inflammation. The hypothesis presented is that the skeletal muscle HO-1/CO system helps modulate components in the MQC cycle during metabolic stress.
- Subjects :
- Inflammation
Carbon Monoxide
Biliverdin
biology
Skeletal muscle
Physical Therapy, Sports Therapy and Rehabilitation
Cell biology
Heme oxygenase
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Stress, Physiological
medicine
biology.protein
Cytochrome c oxidase
Humans
Orthopedics and Sports Medicine
Metabolic Stress
medicine.symptom
Muscle, Skeletal
Heme
Carbon monoxide
Subjects
Details
- ISSN :
- 15383008
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Exercise and sport sciences reviews
- Accession number :
- edsair.doi.dedup.....705ed9537ad7cbb01321260dc7903319