Back to Search
Start Over
Activity of ceftolozane-tazobactam and comparators when tested against Gram-negative isolates collected from paediatric patients in the USA and Europe between 2012 and 2016 as part of a global surveillance programme
- Source :
- International Journal of Antimicrobial Agents. 53:637-643
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Ceftolozane-tazobactam is a combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. Ceftolozane-tazobactam was approved by the US Food and Drug Administration in 2014 and by the European Medicines Agency in 2015 for use in adults to treat complicated urinary tract infections, acute pyelonephritis, and complicated intra-abdominal infections with metronidazole. Studies for paediatric indications are planned. The Programme to Assess Ceftolozane-Tazobactam Susceptibility monitors the resistance of ceftolozane-tazobactam to Gram-negative isolates worldwide. In total, 6240 Gram-negative isolates were collected between 2012 and 2016 from paediatric patients (
- Subjects :
- Male
0301 basic medicine
Klebsiella pneumoniae
Cephalosporin
Antibiotics
medicine.disease_cause
0302 clinical medicine
polycyclic compounds
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
Child
biology
Broth microdilution
General Medicine
Hospitals
Anti-Bacterial Agents
Europe
Infectious Diseases
Amikacin
Child, Preschool
Female
beta-Lactamase Inhibitors
medicine.drug
Microbiology (medical)
Tazobactam
medicine.medical_specialty
Adolescent
medicine.drug_class
030106 microbiology
Microbial Sensitivity Tests
Meropenem
03 medical and health sciences
Internal medicine
Gram-Negative Bacteria
medicine
Humans
Pseudomonas aeruginosa
business.industry
Infant, Newborn
Infant
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
biology.organism_classification
United States
Cephalosporins
Colistin
bacteria
Gram-Negative Bacterial Infections
business
Subjects
Details
- ISSN :
- 09248579
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- International Journal of Antimicrobial Agents
- Accession number :
- edsair.doi.dedup.....70744328d76a4eec5258502a3bfa6512