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Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4
- Source :
- The Journal of Antibiotics. 71:129-134
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The structures of these molecules were determined by spectroscopic studies, advanced Marfey's method and X-ray crystal structural analysis. Valgamicin C contains the extremely rare amino acid cleonine. To our knowledge, this is the first report of a cleonine-containing metabolite from a naturally isolated microorganism without any breeding or mutation treatment. None of the valgamicins showed potent antibacterial activity against either Gram-positive or -negative bacteria. Valgamicins A, C and T exhibited moderate cytotoxicity against human tumor cell lines.The Journal of Antibiotics advance online publication, 15 November 2017; doi:10.1038/ja.2017.135.
- Subjects :
- 0301 basic medicine
Pharmacology
chemistry.chemical_classification
Mutation
biology
010405 organic chemistry
medicine.drug_class
Metabolite
Microorganism
Antibiotics
biology.organism_classification
medicine.disease_cause
01 natural sciences
0104 chemical sciences
Amino acid
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
chemistry
Biochemistry
Drug Discovery
medicine
Cytotoxicity
Antibacterial activity
Bacteria
Subjects
Details
- ISSN :
- 18811469 and 00218820
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- The Journal of Antibiotics
- Accession number :
- edsair.doi.dedup.....70823c9475fa723b33c642bed3868522