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Clinical significance of coronary artery disease in hypertrophic cardiomyopathy
- Source :
- The American journal of cardiology. 70(4)
- Publication Year :
- 1992
-
Abstract
- The role of coronary artery disease (CAD) in hypertrophic cardiomyopathy (HC) has not been thoroughly clarified. To assess the clinical and prognostic significance of these 2 coexistent diseases, 96 patients with HC (62 men, mean age 45 years) who underwent coronary arteriography and 2-dimensional echocardiography were studied. Significant stenosis (greater than 70%) of 1 or more coronary arteries was detected in 11 patients, all aged greater than 45 years. This group, compared with the other group without significant CAD (n = 85), was characterized by an older age (59 +/- 7 vs 42 +/- 15 years; p less than 0.05), a greater prevalence of previous myocardial infarction (24 vs 0%; p less than 0.001), complex ventricular arrhythmias (100 vs 50%; p less than 0.05), non-obstructive forms (82 vs 46%; p less than 0.05), dilated (45 vs 7%; p less than 0.02) and hypocontractile left ventricle (36 vs 6%; p less than 0.01) and higher mortality (36 vs 8%; p less than 0.05) during a mean follow-up of 3.6 years. It is concluded that CAD associated with HC is a complex clinical syndrome, difficult to diagnose clinically, that can reliably be recognized by coronary angiography. CAD seems to play an important role in modifying the pathophysiology, the natural history and the prognosis of HC.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Cardiomyopathy
Coronary Disease
Coronary Angiography
Coronary artery disease
Electrocardiography
Internal medicine
medicine
Humans
Clinical significance
Myocardial infarction
Aged
medicine.diagnostic_test
business.industry
Hypertrophic cardiomyopathy
Hemodynamics
Stroke Volume
Stroke volume
Cardiomyopathy, Hypertrophic
Middle Aged
medicine.disease
Prognosis
Coronary arteries
medicine.anatomical_structure
Echocardiography
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 70
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American journal of cardiology
- Accession number :
- edsair.doi.dedup.....70935d6e3e930f80ac09dd3e1e2553b0