Back to Search
Start Over
Inhibition effect of glycyrrhiza polysaccharide (GCP) on tumor growth through regulation of the gut microbiota composition
- Source :
- Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 324-332 (2018)
- Publication Year :
- 2017
-
Abstract
- Glycyrrhiza Uralensis Polysaccharide (GCP), as a macromolecular polysaccharide extracted from the Traditional Chinese Medicine (TCM) - Licorice has been proved to inhibit tumor growth in vitro and in vivo; however, the specific anti-tumor mechanism of GCP needs to be further investigated. In this study, we explore the anti-tumor mechanism of GCP from the angle of gut microbiota. Colon carcinoma cells (CT-26) were used to set up a tumor-bearing mouse model. After 14 days of GCP treatment, the weights of tumors were significantly reduced. In addition, HE staining of tissue sections reflected that GCP could effectively inhibit tumor metastasis. 16SrRNA high-throughput sequencing of fecal samples showed a significant change between the model group and GCP group in the composition of gut microbiota. Subsequently, gut microbiota depletion and fecal transplantation experiments further confirmed the relationship between the anti-tumor effects of GCP and gut microbiota. Following depletion of gut microbiota, GCP cannot inhibit tumor growth. Fecal transplantation experiments found that transplanting the feces of GCP-treated mice, to a certain extent, could inhibit tumor growth and metastasis. These results indicate that Glycyrrhiza Polysaccharides exert anti-tumor effects by affecting gut microbiota composition. Keywords: Glycyrrhiza Uralensis Polysaccharides, Gut microbiota, Cancer, TCM, Anti-tumor
- Subjects :
- 0301 basic medicine
Male
H&E stain
Gut flora
Polysaccharide
digestive system
Microbiology
Metastasis
03 medical and health sciences
Polysaccharides
Cell Line, Tumor
medicine
Animals
Glycyrrhiza uralensis
Feces
Pharmacology
chemistry.chemical_classification
Mice, Inbred BALB C
biology
lcsh:RM1-950
Cancer
Fecal Microbiota Transplantation
biology.organism_classification
medicine.disease
Antineoplastic Agents, Phytogenic
Gastrointestinal Microbiome
Disease Models, Animal
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Cell Transformation, Neoplastic
chemistry
Colonic Neoplasms
Molecular Medicine
Glycyrrhiza
Phytotherapy
Subjects
Details
- ISSN :
- 13478648
- Volume :
- 137
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of pharmacological sciences
- Accession number :
- edsair.doi.dedup.....709d4bd3c20a203852483a70c2abc754