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Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
- Source :
- Psychol Med, Psychological Medicine, 49(7), 1166-1173. Cambridge University Press, Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal, A, Borglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls ', Psychological Medicine, vol. 49, no. 7, pp. 1166-1173 . https://doi.org/10.1017/S0033291718002039, Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Børglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2019, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls ', Psychological Medicine, vol. 49, no. 7, pp. 1166-1173 . https://doi.org/10.1017/S0033291718002039, Pettersson, E, Lichtenstein, P, Larsson, H, Song, J, Agrawal, A, Børglum, A D, Bulik, C M, Daly, M J, Davis, L K, Demontis, D, Edenberg, H J, Grove, J, Gelernter, J, Neale, B M, Pardiñas, A F, Stahl, E, Walters, J T R, Walters, R, Sullivan, P F, Posthuma, D & Polderman, T J C 2018, ' Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls ' Psychological Medicine . https://doi.org/10.1017/S0033291718002039, Print:0033-2917
- Publication Year :
- 2018
-
Abstract
- BackgroundMost studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.MethodsWe assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.ResultsHeritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.ConclusionsGiven the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.
- Subjects :
- Male
Obsessive-Compulsive Disorder
Anorexia Nervosa
Bipolar Disorder
Autism Spectrum Disorder
alcohol dependence
heritability
anorexia nervosa
Correlation
Cohort Studies
0302 clinical medicine
obsessive compulsive disorder
genes
Applied Psychology
bipolar disorder
education.field_of_study
Mental Disorders
Psychiatry and Mental health
Alcoholism
Autism spectrum disorder
Major depressive disorder
Female
Schizophrenic Psychology
Corrigendum
Adult
medicine.medical_specialty
Genotype
autism spectrum disorders
Population
BF
03 medical and health sciences
Quantitative Trait, Heritable
SDG 3 - Good Health and Well-being
mental disorders
medicine
ADHD
Humans
Family
Bipolar disorder
Sibling
Psychiatry
education
Sweden
Depressive Disorder, Major
major depressive disorder
business.industry
Siblings
Alcohol dependence
Heritability
medicine.disease
030227 psychiatry
schizophrenia
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
RC0321
Schizophrenia
Gene-Environment Interaction
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14698978 and 00332917
- Volume :
- 49
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Psychological medicine
- Accession number :
- edsair.doi.dedup.....70bb8ca3c88773f22861f58631c98c43