Acute leukemia following chlorambucil therapy of advanced ovarian and fallopian tube carcinoma

Acute leukemia developed in two patients, one with advanced ovarian carcinoma and the other with advanced carcinoma of the fallopian tubes. Both patients received chlorambucil as a part of their treatment regimen. The literature is reviewed and updated since the report of Sotrel et al. [Obstet. Gynecol.47, No. 1 (Suppl.), 67s–71s (1976)], and a rationale for the use of high-dose intermittent chlorambucil therapy in the treatment of ovarian carcinoma is presented for consideration.