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Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19
- Source :
- The Journal of Nutrition, Health & Aging
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The objective of this cohort study was to determine whether hypercalcemia in early COVID-19 was associated with 3-month mortality in frail elderly patients. Circulating calcium and albumin concentrations at hospital admission and 3-month mortality were assessed in geriatric patients hospitalized for COVID-19 with normal-to-high calcium concentrations. Hypercalcemia was defined as corrected calcium >2.5mmol/L. Covariables were age, sex, functional abilities, malignancies, hypertension, cardiomyopathy, number of acute health issues, use antibiotics and respiratory treatments. In total, 94 participants (mean±SD 88.0±5.5years;47.9% women;22.3% hypercalcemia;0% hypocalcemia) were included. Sixty-five participants who survived at 3months exhibited less often hypercalcemia at baseline than the others (13.9% versus 41.4%, P=0.003). Hypercalcemia was associated with 3-month mortality (fully-adjusted HR=3.03, P=0.009) with specificity=0.86 and sensitivity=0.41. Those with hypercalcemia had shorter survival time than those with normocalcemia (log-rank P=0.002). In conclusion, hypercalcemia was associated with poorer survival in hospitalized frail elderly COVID-19 patients. © 2021, Serdi-Editions and Springer-Verlag France.
- Subjects :
- Male
Poor prognosis
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Frail Elderly
Cardiomyopathy
Medicine (miscellaneous)
chemistry.chemical_element
Calcium
Cohort Studies
Internal medicine
Humans
Medicine
Frail elderly
Respiratory system
older adults
Aged
calcium
Nutrition and Dietetics
SARS-CoV-2
business.industry
Brief Report
COVID-19
Prognosis
medicine.disease
chemistry
Hypercalcemia
biomarker
Biomarker (medicine)
Female
Geriatrics and Gerontology
business
Biomarkers
Cohort study
Subjects
Details
- ISSN :
- 17604788 and 12797707
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- The journal of nutrition, health & aging
- Accession number :
- edsair.doi.dedup.....70caaa87c46938aa297f42fbd3850e40