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HLA-DRB and -DQB1 alleles in Polish patients with hepatitis B associated membranous nephropathy
- Source :
- Tissue Antigens. 52:130-134
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- We have studied the HLA-DRB and -DQB1 alleles of 42 paediatric patients who have suffered from membranous nephropathy associated with a hepatitis B infection (HBVMN). These patients were all from the Gdansk area of Northern Poland and the disease was diagnosed by light and electron microscopy. The control population consisted of 55 healthy children, approximately age matched, from schools in Gdansk. In addition we have also analysed 40 patients chronically infected with hepatitis B, without any renal involvement, as hepatitis B disease controls. The HLA alleles were defined using PCR/SSP. As idiopathic membranous nephropathy and low responsiveness to hepatitis B vaccine have been found to be associated with DR3 in Caucasoids, our hypothesis was that the HBVMN patients would show an increase in DR3. Our results indicate that, although there is a small increase in the frequency of DRBl*0301 in the HBVMN patients (16/42 38%) when compared to the healthy controls (15/55 31%), this does not approach significance. There is a significant increase in the frequency of DQBl*0303 in the HBVMN patients vs the healthy controls, after correction for the number of antigens detected (P) (13/42 vs 2/55, RR=11.6, P=0.0007, Pc=0.02). A similar increase in DQBl*0303 is seen in the HBVMN patients when compared to the hepatitis controls (13/42 vs 4/40) but this is only significant before correction (RR=4.3, P=0.04).
- Subjects :
- Male
medicine.medical_specialty
Hepatitis B vaccine
Immunology
HLA-DR7 Antigen
Disease
Human leukocyte antigen
Glomerulonephritis, Membranous
Biochemistry
Gastroenterology
HLA-DR3 Antigen
Membranous nephropathy
Antigen
Seroepidemiologic Studies
HLA-DQ Antigens
Internal medicine
Genetics
medicine
HLA-DQ beta-Chains
Humans
Immunology and Allergy
Allele
Antigens, Viral
Alleles
Hepatitis
business.industry
General Medicine
Hepatitis B
medicine.disease
Female
Poland
business
Subjects
Details
- ISSN :
- 13990039 and 00012815
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Tissue Antigens
- Accession number :
- edsair.doi.dedup.....70e1d8f23b2add5afa2a8aac9bde95dd