Back to Search
Start Over
Apparent diffusion coefficient measurements on a novel diffusion weighted MRI phantom utilizing EPI and HASTE sequences
- Source :
- Physica Medica. 73:179-189
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Purpose The aim of this study is to introduce a novel DWI-MRI phantom and to compare Apparent Diffusion Coefficient (ADC) measurements, utilizing EPI-DWI and HASTE-DWI sequences and two different fitting algorithms. Materials and Methods 23 test tubes with different sucrose concentrations and polyacrylamide gels were used as a phantom for ADC measurements. The phantom was scanned on a clinical MRI system (1.5 T) over a two-month period utilizing an EPI-DWI and a HASTE-DWI sequence. ADC maps were calculated using a Weighted Linear (WL) and a Non Linear (NL) fitting algorithm. Measurements were performed with two sequences and two fitting algorithms. Geometric Distortions (GD), Ghosting Ratios (GR) and Signal to Structured Noise Ratios (SSNRs) were estimated using both sequences from the resultant ADC parametric maps. Results Polyacrylamide gels reveal lower coefficient of variation (CV%) as compared to sucrose solutions. ADC measurements performed with WL and NL algorithms reveal identical results with both sequences. WL and NL algorithms require approx. 3 s and 7 min respectively, for a single slice. EPI-DWI reveals a mean percent ADC value difference of (+4.5%) as compared to HASTE-DWI, regardless the type of fitting algorithm. Conclusion Polyacrylamide gels can serve as a better means for simulating ADC values, compared with sucrose solutions used in this study. WL can be proposed as the method for ADC measurements in daily clinical practice. WL is significantly faster than NL fitting method and equally precise. SSNR measured directly on ADC maps is an excellent means for testing the precision of ADC measurements.
- Subjects :
- Materials science
Phantoms, Imaging
Coefficient of variation
Biophysics
General Physics and Astronomy
General Medicine
Noise (electronics)
Imaging phantom
030218 nuclear medicine & medical imaging
body regions
03 medical and health sciences
Diffusion Magnetic Resonance Imaging
0302 clinical medicine
030220 oncology & carcinogenesis
Fitting algorithm
Linear Models
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Ghosting
Biomedical engineering
Parametric statistics
Diffusion MRI
Subjects
Details
- ISSN :
- 11201797
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Physica Medica
- Accession number :
- edsair.doi.dedup.....70e8677a18394e7613e6fc7d59957241
- Full Text :
- https://doi.org/10.1016/j.ejmp.2020.04.024