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Apparent diffusion coefficient measurements on a novel diffusion weighted MRI phantom utilizing EPI and HASTE sequences

Authors :
Apostolos H. Karantanas
Sofia Gourtsoyianni
Konstantinos Marias
G. Kalaitzakis
T. Boursianis
G. Lymperopoulou
Georgios Gourzoulidis
Thomas G. Maris
Source :
Physica Medica. 73:179-189
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

Purpose The aim of this study is to introduce a novel DWI-MRI phantom and to compare Apparent Diffusion Coefficient (ADC) measurements, utilizing EPI-DWI and HASTE-DWI sequences and two different fitting algorithms. Materials and Methods 23 test tubes with different sucrose concentrations and polyacrylamide gels were used as a phantom for ADC measurements. The phantom was scanned on a clinical MRI system (1.5 T) over a two-month period utilizing an EPI-DWI and a HASTE-DWI sequence. ADC maps were calculated using a Weighted Linear (WL) and a Non Linear (NL) fitting algorithm. Measurements were performed with two sequences and two fitting algorithms. Geometric Distortions (GD), Ghosting Ratios (GR) and Signal to Structured Noise Ratios (SSNRs) were estimated using both sequences from the resultant ADC parametric maps. Results Polyacrylamide gels reveal lower coefficient of variation (CV%) as compared to sucrose solutions. ADC measurements performed with WL and NL algorithms reveal identical results with both sequences. WL and NL algorithms require approx. 3 s and 7 min respectively, for a single slice. EPI-DWI reveals a mean percent ADC value difference of (+4.5%) as compared to HASTE-DWI, regardless the type of fitting algorithm. Conclusion Polyacrylamide gels can serve as a better means for simulating ADC values, compared with sucrose solutions used in this study. WL can be proposed as the method for ADC measurements in daily clinical practice. WL is significantly faster than NL fitting method and equally precise. SSNR measured directly on ADC maps is an excellent means for testing the precision of ADC measurements.

Details

ISSN :
11201797
Volume :
73
Database :
OpenAIRE
Journal :
Physica Medica
Accession number :
edsair.doi.dedup.....70e8677a18394e7613e6fc7d59957241
Full Text :
https://doi.org/10.1016/j.ejmp.2020.04.024