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Prenatal mercury exposure, fish intake and neurocognitive development during first three years of life: Prospective cohort mothers and Children's environmental health (MOCEH) study
- Source :
- Science of The Total Environment. 615:1192-1198
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objectives In this prospective cohort study, the effects of prenatal Hg exposure on neurocognitive development during the first 3 years of life were investigated. Methods The maternal blood levels of Hg were assessed during pregnancy and in cord blood. Maternal fish intake was assessed by interviewing the weekly frequency of fish intake during pregnancy. Maternal n-3 and n-6 fatty acid intake was estimated based on 24 h recall food intake interview. The mental (MDI) and psychomotor (PDI) development index scores were assessed using the Bayley Scales of Infant Development at 6, 12, 24, 36 months of age. Results The geometric mean of the maternal blood Hg concentration was 3.3 μg/L (10th percentile = 1.81; 90th = 5.91) during the early pregnancy, 3.0 μg/L (10th = 1.68; 90th = 5.57) during late pregnancy, and 5.1 μg/L (10th = 2.94; 90th = 8.93) in cord blood. After adjusting for weekly frequency of fish intake, the blood Hg concentrations during early pregnancy showed association with the adjusted MDI (β = − 0.408, p = 0.048) and PDI scores (β = − 0.550, p = 0.031) at 6 months. After further adjusting for n-3 and n-6 fatty acids estimated based on 24 h recall of food intake, the blood Hg concentrations during early pregnancy showed association with the MDI (β = − 0.489, p = 0.026) and PDI (β = − 0.664, p = 0.015) at 6 months. Conclusion These results show that prenatal Hg exposure during early pregnancy adversely associated with early neurodevelopment during infancy, after adjusting for fish and n-3, n-6 fatty acid intake. Consuming fish high in fatty acids and low in Hg during early pregnancy may be important to neurocognitive development at early infancy.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Environmental Engineering
Physiology
Food Contamination
Neuropsychological Tests
010501 environmental sciences
01 natural sciences
Bayley Scales of Infant Development
Dietary Exposure
03 medical and health sciences
Child Development
0302 clinical medicine
Pregnancy
Humans
Environmental Chemistry
Medicine
Prospective Studies
030212 general & internal medicine
Child
Prospective cohort study
Waste Management and Disposal
0105 earth and related environmental sciences
chemistry.chemical_classification
Psychomotor learning
business.industry
Infant
Fatty acid
Mercury
medicine.disease
Pollution
chemistry
Maternal Exposure
Prenatal Exposure Delayed Effects
Cord blood
Environmental Pollutants
Female
business
Neurocognitive
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 00489697
- Volume :
- 615
- Database :
- OpenAIRE
- Journal :
- Science of The Total Environment
- Accession number :
- edsair.doi.dedup.....70f2882bcbc6b50b9933f29e25a1b770