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Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Surgically Treated Stage I Lung Adenocarcinoma Patients
- Source :
- Clinical Nuclear Medicine
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Purpose of the report This article aims to explore the prognostic role of 18F-FDG PET/CT metabolic parameters in stage I lung adenocarcinoma patients. Patients and methods One hundred eighty pathological stage I lung adenocarcinoma patients were retrospectively reviewed. Semiquantitative analysis of FDG tumor uptake was performed with TrueD software on the Siemens Leonardo workstation. SUVmean and MTV were calculated using SUV threshold of 41% of SUVmax; the total lesion glycolysis (TLG) was calculated as the product of SUVmean and MTV. Correlation was evaluated using Spearman correlation coefficient. Maximally selected rank statistics was performed to detect the optimal cutoff used for dichotomizing each PET parameter (6.5 for SUVmean, 9.6 for SUVmax, and 19.1 for TLG). Results Our main finding was the significant correlation between 18F-FDG PET/CT parameters (SUVmean, SUVmax, and TLG) and disease-free survival in pathologic stage I non-small cell lung cancer. SUVmean has the greatest accuracy in recurrence prediction (integrated area under the curve, 0.803; 95% confidence interval, 0.689-0.918). We run the maximally selected rank statistics to provide the classification of observations in 2 groups by a continuous predictor parameter; the free from recurrence rate was significantly greater in patients with SUVmean ≤6.5, SUVmax ≤9.6, and TLG ≤19.1. Conclusions Our research supports the hypothesis that SUVmean, SUVmax, and TLG are well correlated with free from recurrence rate in stage I adenocarcinoma patients, subjected to pulmonary lobectomy. Our findings also indicate these markers as promising prognostic indicators.
- Subjects :
- Adult
Male
metabolic parameters
Lung Neoplasms
PET/CT
Spearman's rank correlation coefficient
Disease-Free Survival
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Pulmonary lobectomy
Carcinoma, Non-Small-Cell Lung
Positron Emission Tomography Computed Tomography
80 and over
medicine
Humans
prognostic value
Radiology, Nuclear Medicine and imaging
Non-Small-Cell Lung
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
PET-CT
pulmonary lobectomy
business.industry
Carcinoma
Area under the curve
Retrospective cohort study
Original Articles
lung adenocarcinoma
Glycolysis
Middle Aged
Prognosis
Tumor Burden
General Medicine
medicine.disease
Confidence interval
030220 oncology & carcinogenesis
Stage I Lung Adenocarcinoma
Adenocarcinoma
Nuclear medicine
business
Subjects
Details
- ISSN :
- 15360229 and 03639762
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Clinical Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....70f377ae56e1c2f591e7761afee731a5