Figure S2 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

Supplementary Figure 2 | Significantly mutated genes AKT1, PIK3R1, ERBB3, FBXW7, ATM, CHEK2 and MYO3A. Schematics of the identified novel significantly mutated genes (A) AKT1, (B) PIK3R1, (C) ERBB3, (D) FBXW7, (E) ATM, (F) CHEK2 and (G) MYO3A in OCCC. Mutation marks are shown in black (truncating), red (SIFT and PolyPhen damaging prediction), yellow (SIFT or PolyPhen damaging prediction) or white (SIFT and PolyPhen benign prediction). Mutation effects are indicated with a black spot when paired control was available and written in black (previously described mutation) or red (novel mutations).