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Bone structure assessed with pQCT in prepubertal males with delayed puberty or congenital hypogonadotropic hypogonadism
- Source :
- Clinical endocrinologyREFERENCES. 95(1)
- Publication Year :
- 2021
-
Abstract
- Objective Congenital hypogonadotropic hypogonadism (CHH) is associated with impaired bone mineral density in adulthood, whereas the estimates on bone structure in adolescents with CHH has not been previously evaluated. Design This cross-sectional study describes bone structure in CHH patients and compares it to that in boys with constitutional delay of growth and puberty (CDGP). Methods Peripheral quantitative computed tomography (pQCT) of non-dominant arm and left leg were performed in five treatment-naive males diagnosed with CHH and in 24 males with CDGP. Volumetric bone mineral density (BMD), bone mineral content, and area in trabecular and cortical bone compartments were evaluated, and bone age-adjusted Z-scores for the bone parameters were determined. Results The participants with CHH had more advanced bone age and were older, taller, and heavier than the CDGP boys, yet they had lower trabecular BMD in distal radius (147.7 mg/mm3 [95%CI, 128-168 mg/mm3 ] vs. 181.2 mg/mm3 [172-192 mg/mm3 ], p=0.002) and distal tibia (167.6 mg/mm3 [145-190 mg/mm3 ] vs. 207.2 mg/mm3 [187-227 mg/mm3 ], p=0.012), respectively. CHH males had lower cortical thickness at diaphyseal tibia than the participants with CDGP (p=0.001). These between-group differences remained significant in corresponding Z-scores adjusted for bone age and height (p=0.001). In CDGP group, serum testosterone correlated positively with trabecular BMD (r=0.51, p=0.013) at distal radius, and estradiol levels correlated positively with trabecular BMD at the distal site of tibia (r=0.58, p=0.004). Conclusions Five treatment-naive male patients with CHH exhibited poorer trabecular BMD than untreated males with CDGP. We speculate that timely low-dose sex steroid replacement in CHH males may benefit skeletal health in adulthood.
- Subjects :
- Delayed puberty
Adult
Male
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Bone and Bones
03 medical and health sciences
0302 clinical medicine
Endocrinology
Bone Density
Internal medicine
Medicine
Humans
Tibia
peripheral quantitative computed tomography
Quantitative computed tomography
Bone mineral
Puberty, Delayed
medicine.diagnostic_test
business.industry
Hypogonadism
Bone age
16. Peace & justice
delayed puberty
Radius
medicine.anatomical_structure
Cross-Sectional Studies
Sex steroid
3121 General medicine, internal medicine and other clinical medicine
030220 oncology & carcinogenesis
Cortical bone
Congenital Hypogonadotropic Hypogonadism
medicine.symptom
business
Subjects
Details
- ISSN :
- 13652265
- Volume :
- 95
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinologyREFERENCES
- Accession number :
- edsair.doi.dedup.....710462ba8fa356578d4e92715d08d07b