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Stereoarrayed CF3 -Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation
- Source :
- Angewandte Chemie International Edition, Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (17), pp.5294-5298. ⟨10.1002/anie.201600812⟩
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- CF3 -substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3 -substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3 C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction.
- Subjects :
- Formic acid
010405 organic chemistry
Enantioselective synthesis
Noyori asymmetric hydrogenation
chemistry.chemical_element
General Chemistry
General Medicine
Transfer hydrogenation
010402 general chemistry
Medicinal chemistry
01 natural sciences
Catalysis
Ruthenium
Kinetic resolution
0104 chemical sciences
chemistry.chemical_compound
chemistry
[CHIM]Chemical Sciences
Organic chemistry
Triethylamine
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- ISSN :
- 00448249, 14337851, and 15213773
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....711c1df61b5a01e89db1503c45eeed56
- Full Text :
- https://doi.org/10.1002/ange.201600812