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Bismuth chelate as a contrast agent for X-ray computed tomography
- Source :
- Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-10 (2020), Journal of Nanobiotechnology
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Backgrounds Due to the unexpected side effects of the iodinated contrast agents, novel contrast agents for X-ray computed tomography (CT) imaging are urgently needed. Nanoparticles made by heavy metal elements are often employed, such as gold and bismuth. These nanoparticles have the advantages of long in vivo circulation time and tumor targeted ability. However, due to the long residence time in vivo, these nanoparticles may bring unexpected toxicity and, the preparation methods of these nanoparticles are complicated and time—consuming. Methods In this investigation, a small molecular bismuth chelate using diethylenetriaminepentaacetic acid (DPTA) as the chelating agent was proposed to be an ideal CT contrast agent. Results The preparation method is easy and cost—effective. Moreover, the bismuth agent show better CT imaging for kidney than iohexol in the aspect of improved CT values. Up to 500 µM, the bismuth agent show negligible toxicity to L02 cells and negligible hemolysis. And, the bismuth agent did not induce detectable morphology changes to the main organs of the mice after intravenously repeated administration at a high dose of 250 mg/kg. The pharmacokinetics of the bismuth agent follows the first—order elimination kinetics and, it has a short half—life time of 0.602 h. The rapid clearance from the body promised its excellent biocompatibility. Conclusions This bismuth agent may serve as a potential candidate for developing novel contrast agent for CT imaging in clinical applications.
- Subjects :
- lcsh:Medical technology
Biocompatibility
Iohexol
lcsh:Biotechnology
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
chemistry.chemical_element
Nanoparticle
Contrast Media
Metal Nanoparticles
Bioengineering
02 engineering and technology
010402 general chemistry
Kidney
01 natural sciences
Applied Microbiology and Biotechnology
Bismuth
Mice
Iodinated contrast
Pharmacokinetics
In vivo
lcsh:TP248.13-248.65
medicine
Animals
Chelation
Tissue Distribution
Whole Body Imaging
Bismuth agent
X-ray computed tomography
Chemistry
Research
Pentetic Acid
021001 nanoscience & nanotechnology
0104 chemical sciences
lcsh:R855-855.5
Molecular Medicine
DTPA
0210 nano-technology
Tomography, X-Ray Computed
Biomedical engineering
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14773155
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Nanobiotechnology
- Accession number :
- edsair.doi.dedup.....71229069e7793a54a67264e8c25b7282