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Mucosal healing in intestinal Behçet's disease: A systematic review and meta‐analysis
- Source :
- Journal of Digestive Diseases. 22:83-90
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- OBJECTIVES Behcet's disease (BD) is a chronic inflammatory disease characterized by recurrent oral aphthous ulcers, intestinal lesions, genital ulcers, uveitis, and skin lesions. Evidence regarding mucosal healing for the prognosis of intestinal BD is scarce. The aim of this systematic review and meta-analysis was to determine the association between mucosal healing and long-term outcomes of patients with intestinal BD. METHODS Relevant studies were identified in a comprehensive search of PubMed, Cochrane Library, and EMBASE databases. Studies reporting long-term outcomes of mucosal healing in patients with intestinal BD were included. Pooled risk ratio (RR) and 95% confidence interval (CI) for disease recurrence and surgery were calculated using the Mantel-Haenszel random-effects models. Heterogeneity among the eligible studies was evaluated using the Q test and I2 statistics. RESULTS Of the 4785 studies initially identified, 8 were finally included. The pooled RR for the association between mucosal healing and disease recurrence was 0.41 (95% CI 0.30-0.57, P
- Subjects :
- medicine.medical_specialty
Behcet's disease
Disease
Cochrane Library
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
business.industry
Behcet Syndrome
Confounding
Prognosis
medicine.disease
Confidence interval
Intestines
Intestinal Diseases
030220 oncology & carcinogenesis
Meta-analysis
Relative risk
Stomatitis, Aphthous
030211 gastroenterology & hepatology
business
Uveitis
Subjects
Details
- ISSN :
- 17512980 and 17512972
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Digestive Diseases
- Accession number :
- edsair.doi.dedup.....712fc4eb2f3dc8c9c54daf7e21a9ec7f