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Management trends and outcomes of breast angiosarcoma: Is breast conservation feasible?

Management trends and outcomes of breast angiosarcoma: Is breast conservation feasible?

Authors :
Rodney E. Wegner
Mark G. Trombetta
Thomas B. Julian
Vivek Verma
April Metzger
Shaakir Hasan
Christie Hilton
Source :
The Breast Journal. 25:1230-1234
Publication Year :
2019
Publisher :
Hindawi Limited, 2019.

Abstract

We queried the National Cancer Database for nonmetastatic breast angiosarcoma, yielding 808 patients (202 de novo, 606 secondary). The median survival was 53.7 months. Secondary tumors were more likely to undergo mastectomy than de novo lesions (OR = 3.99, P 0.001). Treatments included lumpectomy (10%), lumpectomy/radiation (3%), mastectomy alone (73%), or mastectomy/radiation (14%), with no difference in survival (P = 0.68). Lumpectomy correlated with positive margin rate (OR 3.29), which was a predictor for death (HR = 2.37, P 0.01), along with older age, higher comorbidity scores, size5 cm, and high-grade disease (P 0.05). While breast angiosarcoma is usually treated with mastectomy, lumpectomy may be feasible for well-selected tumors.

Details

ISSN :
15244741 and 1075122X
Volume :
25
Database :
OpenAIRE
Journal :
The Breast Journal
Accession number :
edsair.doi.dedup.....713bfa472d8436d786cff15878267424
Full Text :
https://doi.org/10.1111/tbj.13439