Back to Search Start Over

Supplementary Tables S1-S3 and Supplementary Figures S1-S6 from Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL

Authors :
Scott A. Armstrong
Andrew L. Kung
James E. Bradner
Andrei V. Krivtsov
Jun Qi
Matthew Witkin
Janna Minehart
Sridhar Vempati
Tina Davis
Megan Bariteau
Wonil Kim
Matthew C. Stubbs
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Tables S1-S3 and Supplementary Figures S1-S6. Table S1 - EC50 values for B-cell malignancies treated with HDAC inhibitors of varying isoform selectivity Table S2 - EC50 values for B-ALL cell line treated with a panel of HDAC inhibitors Table S3 - statistics for cell growth assay in Figure 3 Figure S1 - In vitro survival and PD for B-ALL cells treated with LAQ824 Figure S2 - Western analyses of B-ALL cells treated with MS275 Figure S3 - Western blots, cell growth and cell cycle analysis for B-ALL cells transduced with HDAC1,2, or 3 specific shRNA Figure S4 - Western analyses, cell growth and survival of B-ALL cell treated with Merck60 Figure S5 - Survival and western blots for B-ALL cells treated with HDACi with an apoptosis inhibitor. Figure S6 - Western blots to show DNA damage caused by HDACi or doxorubicin in Merck60 insensitive multiple myeloma cell lines.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....7143001f9200b368a485c2b60c71fd9a
Full Text :
https://doi.org/10.1158/1078-0432.22457499