Back to Search
Start Over
Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry
- Source :
- International journal of hyperthermia, 31(6), 609-614. Informa Healthcare, International Journal of Hyperthermia, 31(6), 609-614. Informa Healthcare
- Publication Year :
- 2015
-
Abstract
- Purpose: Hyperthermia has been shown to improve the effectiveness of chemotherapy and radiotherapy in the treatment of cancer. This paper summarises all recent clinical trials registered in the ClinicalTrials.gov registry. Materials and methods: The records of 175,538 clinical trials registered at ClinicalTrials.gov were downloaded on 29 September 2014 and a database was established. We searched this database for hyperthermia or equivalent words. Results: A total of 109 trials were identified in which hyperthermia was part of the treatment regimen. Of these, 49 trials (45%) had hyperthermic intraperitoneal chemotherapy after cytoreductive surgery (HIPEC) as the primary intervention, and 14 other trials (13%) were also testing some form of intraperitoneal hyperthermic chemoperfusion. Seven trials (6%) were testing perfusion attempts to other locations (thoracic/pleural n = 4, limb n = 2, hepatic n = 1). Sixteen trials (15%) were testing regional hyperthermia, 13 trials (12%) whole body hyperthermia, seven trials (6%) superficial hyperthermia and two trials (2%) interstitial hyperthermia. One remaining trial tested laser hyperthermia. Conclusions: In contrast to the general opinion, this analysis shows continuous interest and ongoing clinical research in the field of hyperthermia. Interestingly, the majority of trials focused on some form of intraperitoneal hyperthermic chemoperfusion. Despite the high number of active clinical studies, HIPEC is a topic with limited attention at the annual meetings of the European Society for Hyperthermic Oncology and the Society of Thermal Medicine. The registration of on-going clinical trials is of paramount importance for the achievement of a comprehensive overview of available clinical research activities involving hyperthermia.
- Subjects :
- Hyperthermia
Regional hyperthermia
Cancer Research
medicine.medical_specialty
Physiology
medicine.medical_treatment
610 Medicine & health
2737 Physiology (medical)
SDG 3 - Good Health and Well-being
Physiology (medical)
Internal medicine
Neoplasms
Medicine
Humans
1306 Cancer Research
Registries
Chemotherapy
Clinical Trials as Topic
business.industry
Cancer
1314 Physiology
Hyperthermia, Induced
medicine.disease
10044 Clinic for Radiation Oncology
Cancer treatment
Surgery
Clinical trial
Radiation therapy
Hyperthermic intraperitoneal chemotherapy
business
Subjects
Details
- ISSN :
- 14645157 and 02656736
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
- Accession number :
- edsair.doi.dedup.....71437abfd1d399be4d2af50b0448791f