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Peripheral oxytocin receptors inhibit the nociceptive input signal to spinal dorsal horn wide-dynamic-range neurons
- Source :
- Pain. 158(11)
- Publication Year :
- 2017
-
Abstract
- Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn participate in a selective inhibition of the neuronal activity mediated by Aδ and C fibers but not Aβ fibers. This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral OT blocked the first sensorial activity of Aδ and C fibers recorded in the spinal cord neurons. Furthermore, using the formalin behavioral nociceptive test, we demonstrated that only ipsilateral OTR activation inhibits pain behavior. Our data are reinforced by the fact that the OTR protein is expressed in the sciatic nerve. Consistent with this, immunofluorescence of primary afferent fibers suggest that OTRs could be located in nociceptive-specific terminals of the skin. Taken together, our results suggest that OTRs could be found in nociceptive terminals and that on activation they are able to inhibit nociceptive input.
- Subjects :
- 0301 basic medicine
Male
Nociception
Time Factors
Calcitonin Gene-Related Peptide
Action Potentials
Oxytocin
Piperazines
03 medical and health sciences
0302 clinical medicine
Formaldehyde
Lectins
Premovement neuronal activity
Medicine
Animals
Rats, Wistar
Receptor
Pain Measurement
Nerve Fibers, Unmyelinated
Camphanes
Dose-Response Relationship, Drug
business.industry
Spinal cord
Oxytocin receptor
Electric Stimulation
Rats
Posterior Horn Cells
Electrophysiology
030104 developmental biology
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Neurology
Spinal Cord
Receptors, Oxytocin
Terminal nerve
Neurology (clinical)
Sciatic nerve
business
Neuroscience
030217 neurology & neurosurgery
Psychomotor Performance
Subjects
Details
- ISSN :
- 18726623
- Volume :
- 158
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Pain
- Accession number :
- edsair.doi.dedup.....71567f83c5878bab5e314edd56d8d88e