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Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease
- Source :
- The American journal of clinical nutrition. 70(5)
- Publication Year :
- 1999
-
Abstract
- BACKGROUND Elevated blood homocysteine is a risk factor for cardiovascular disease. A 5-micromol/L increase is associated with an approximately 70% increase in relative risk of cardiovascular disease in adults. For patients with established risk factors, this risk is likely even greater. OBJECTIVE Effects of increased dietary folate and recommended intakes of vitamins B-12 and B-6 on serum total homocysteine (tHcy) were assessed in individuals at high risk of cardiovascular disease. DESIGN This trial was conducted at 10 medical research centers in the United States and Canada and included 491 adults with hypertension, dyslipidemia, type 2 diabetes, or a combination thereof. Participants were randomly assigned to follow a prepared meal plan (PMP; n = 244) or a self-selected diet (SSD; n = 247) for 10 wk, which were matched for macronutrient content. The PMP was fortified to provide >/=100% of the recommended dietary allowances for 23 micronutrients, including folate. RESULTS Mean folate intakes at 10 wk were 601 +/- 143 microgram/d with the PMP and 270 +/- 107 microgram/d with the SSD. With the PMP, serum tHcy concentrations fell from 10.8 +/- 5.8 to 9.3 +/- 4.9 micromol/L (P < 0.0001) between weeks 0 and 10 and the change was associated with increased intakes of folate, vitamin B-12, and vitamin B-6 and with increased serum and red blood cell folate and serum vitamin B-12 concentrations. tHcy concentrations did not change significantly with the SSD. CONCLUSIONS The PMP resulted in increased intakes and serum concentrations of folate and vitamin B-12. These changes were associated with reduced serum tHcy concentrations in persons at high risk of cardiovascular disease.
- Subjects :
- Vitamin
Adult
Male
medicine.medical_specialty
Homocysteine
Medicine (miscellaneous)
Hyperlipidemias
Type 2 diabetes
chemistry.chemical_compound
Folic Acid
Risk Factors
Internal medicine
medicine
Humans
Vitamin B12
Risk factor
Aged
Analysis of Variance
Nutrition and Dietetics
business.industry
Pyridoxine
Middle Aged
medicine.disease
Micronutrient
Diet
B vitamins
Vitamin B 12
Endocrinology
chemistry
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Food, Fortified
Hypertension
Female
business
Dyslipidemia
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 70
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The American journal of clinical nutrition
- Accession number :
- edsair.doi.dedup.....7183b5b5f9a210090773a852140c6e04