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Differentiating T2 hyperintensity in neonatal white matter by two-compartment model of diffusional kurtosis imaging
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- In conventional neonatal MRI, the T2 hyperintensity (T2h) in cerebral white matter (WM) at term-equivalent age due to immaturity or impairment is still difficult to identify. To clarify such issue, this study used the metrics derived from a two-compartment WM model of diffusional kurtosis imaging (WM-DKI), including intra-axonal, extra-axonal axial and radial diffusivities (Da, De,// and De,⊥), to compare WM differences between the simple T2h and normal control for both preterm and full-term neonates, and between simple T2h and complex T2h with hypoxic-ischemic encephalopathy (HIE). Results indicated that compared with control, the simple T2h showed significantly increased De,// and De,⊥, but no significant change in Da in multiple premyelination regions, indicative of expanding extra-axonal diffusion microenvironment; while myelinated regions showed no changes. However, compared with simple T2h, the complex T2h with HIE had decreased Da, increased De,⊥ in both premyelination and myelinated regions, indicative of both intra- and extra-axonal diffusion alterations. While diffusion tensor imaging (DTI) failed to distinguish simple T2h from complex T2h with HIE. In conclusion, superior to DTI-metrics, WM-DKI metrics showed more specificity for WM microstructural changes to distinguish simple T2h from complex T2h with HIE.
- Subjects :
- Pathology
medicine.medical_specialty
Encephalopathy
Article
White matter
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Image Interpretation, Computer-Assisted
medicine
Humans
Brain Diseases
Multidisciplinary
medicine.diagnostic_test
Cerebral white matter
business.industry
Compartment (ship)
Brain
Infant
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
White Matter
Hyperintensity
medicine.anatomical_structure
nervous system
Kurtosis
business
030217 neurology & neurosurgery
Infant, Premature
Diffusion MRI
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....7183c3b4e2c583e837da0c7de8a4bfcd