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Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum
- Source :
- Bioorganicmedicinal chemistry letters. 27(5)
- Publication Year :
- 2016
-
Abstract
- New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2-) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.
- Subjects :
- Stereochemistry
Cell Survival
Neutrophils
Coral
medicine.medical_treatment
Clinical Biochemistry
Anti-Inflammatory Agents
Pharmaceutical Science
01 natural sciences
Biochemistry
Steroid
chemistry.chemical_compound
Inhibitory Concentration 50
Superoxides
Cell Line, Tumor
Drug Discovery
medicine
Animals
Humans
Cytotoxicity
Molecular Biology
010405 organic chemistry
Superoxide
Organic Chemistry
Elastase
Anthozoa
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Cancer cell
Molecular Medicine
Steroids
Klyxum flaccidum
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 27
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....7183db33cc6ce58b3b221b71a0c623e0