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The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study
- Source :
- Reproductive Biology and Endocrinology, Vol 8, Iss 1, p 151 (2010), Reproductive Biology and Endocrinology : RB&E
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Background Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary syndrome (PCOS). However, there are limited data on serum lipocalin-2 levels in patients with PCOS. The aim of the present study was to assess serum lipocalin-2 levels in PCOS. Methods We studied 200 patients with PCOS and 50 healthy female volunteers. Results Serum lipocalin-2 levels were slightly higher in women with PCOS compared with controls (65.4 +/- 34.3 vs. 60.3 +/- 26.0 ng/ml, respectively) but this difference did not reach statistical significance. In contrast, lipocalin-2 levels were higher in overweight/obese women with PCOS than in normal weight women with the syndrome (76.2 +/- 37.3 vs. 54.5 +/- 27.2 ng/ml, respectively; p < 0.001). Serum lipocalin-2 levels were also higher in overweight/obese controls compared with normal weight controls (70.1 +/- 24.9 vs. 50.5 +/- 23.7 ng/ml, respectively; p = 0.004). In the total study population (patients with PCOS and controls), lipocalin-2 levels were independently correlated with the body mass index (p < 0.001). In women with PCOS, lipocalin-2 levels were independently correlated with the waist (p < 0.001). Conclusions Obesity is associated with elevated serum lipocalin-2 levels. In contrast, PCOS does not appear to affect lipocalin-2 levels.
- Subjects :
- Adult
medicine.medical_specialty
Waist
lcsh:QH471-489
Adipokine
Overweight
lcsh:Gynecology and obstetrics
Endocrinology
Insulin resistance
Lipocalin-2
Proto-Oncogene Proteins
Internal medicine
medicine
Humans
lcsh:Reproduction
Obesity
lcsh:RG1-991
integumentary system
business.industry
Research
nutritional and metabolic diseases
Obstetrics and Gynecology
medicine.disease
Polycystic ovary
Lipocalins
Cross-Sectional Studies
Reproductive Medicine
Population study
Female
Insulin Resistance
medicine.symptom
business
Body mass index
Acute-Phase Proteins
Polycystic Ovary Syndrome
Developmental Biology
Subjects
Details
- ISSN :
- 14777827
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Reproductive Biology and Endocrinology
- Accession number :
- edsair.doi.dedup.....7189e3c403a6acb06d6bed54bf000146