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Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet
- Source :
- Lipids in Health and Disease, Vol 10, Iss 1, p 96 (2011), Lipids in Health and Disease
- Publication Year :
- 2011
- Publisher :
- BMC, 2011.
-
Abstract
- Background Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to cardiovascular system, but most of these micronutrients are removed by the refining process. The aim of this study was to determine the effect of rapeseed oil fortified with these micronutrients on the atherosclerosis risk factors in rats fed a high-fat diet. Methods The rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified refined rapeseed oil with low, middle and high quantities of these micronutrients (L-, M- and H-FRRO). Forty male SD rats were divided into four groups. One group received RRO diet and other groups received L-, M- and H-FRRO diet for 10 weeks. Results Micronutrients supplementation significantly increased plasma antioxidant defense capacities, as evaluated by the significant elevation in the activities of GPx, CAT and SOD as well as the level of GSH, and the significant decline in lipid peroxidation. These micronutrients also reduced the plasma contents of TG, TC and LDL-C and increased the ratio of HDL-C/LDL-C. In addition, in parallel with the enhancement of these micronutrients, plasma levels of IL-6 and CRP declined remarkably. Conclusion Rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent atherogenesis by ameliorating plasma oxidative stress, lipid profile and inflammation.
- Subjects :
- Male
Rapeseed
Antioxidant
medicine.medical_treatment
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Drug Evaluation, Preclinical
Tocopherols
Antioxidants
Lipid peroxidation
Fatty Acids, Monounsaturated
Rats, Sprague-Dawley
chemistry.chemical_compound
Endocrinology
Risk Factors
Plasma lipids
Rapeseed oil
Food science
Micronutrients
lcsh:RC620-627
medicine.diagnostic_test
Phytosterols
Micronutrient
Catalase
Glutathione
Lipids
lcsh:Nutritional diseases. Deficiency diseases
C-Reactive Protein
Biochemistry
Food, Fortified
Lipidology
Clinical chemistry
Thiobarbituric Acid Reactive Substances
medicine
Animals
Plant Oils
Enzyme Assays
Biochemistry, medical
Inflammation
Glutathione Peroxidase
Cholesterol
Interleukin-6
Superoxide Dismutase
Research
Biochemistry (medical)
Cholesterol, HDL
Polyphenols
Cholesterol, LDL
Atherosclerosis
Dietary Fats
Rats
chemistry
Lipid Peroxidation
Oxidant stress
Lipid profile
Subjects
Details
- Language :
- English
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....7198070161d3dbf190d8a6dbe9fb4360