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Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors
- Source :
- ChemMedChem. 17
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Herein we report the structure-activity and structure-physicochemical property relationships of a series of class I selective ortho-aminoanilides targeting the "foot-pocket" in HDAC12. To balance the structural benefits and the physicochemical disadvantages of these substances, we started with a set of HDACi related to tacedinaline (CI-994) and evaluated their solubility, lipophilicity (log D
Details
- ISSN :
- 18607187 and 18607179
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- ChemMedChem
- Accession number :
- edsair.doi.dedup.....719df0fdda32b3c206d20d07a15eaf64