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HPV6b virus like particles are potent immunogens without adjuvant in man
- Source :
- Vaccine. 18(11-12)
- Publication Year :
- 1999
-
Abstract
- Subjects with genital warts were immunized three times or more with HPV6b VLPs without adjuvant. All immunized subjects had DTH to HPV6b L1 protein. Of 32 subjects, nine had HPV6b specific antibody prior to immunization and 22 acquired antibody with immunization. VLP specific antibody increased following a single immunization in 6 of 8 subjects with low level antibody at recruitment. Complete regression of genital warts was observed in 25 of 33 evaluable subjects over the 20-week observation period. We conclude that immunization with HPV6b L1 VLPs without adjuvant induces immunity to the L1 protein epitopes recognised during natural infection, and may accelerate regression of warts.
- Subjects :
- Adult
Adolescent
animal diseases
medicine.medical_treatment
chemical and pharmacologic phenomena
Biology
Antibodies, Viral
Epitope
Genital warts
Capsid
Virus-like particle
Antigen
medicine
Humans
Hypersensitivity, Delayed
Papillomaviridae
General Veterinary
General Immunology and Microbiology
Public Health, Environmental and Occupational Health
virus diseases
Viral Vaccines
biochemical phenomena, metabolism, and nutrition
Middle Aged
medicine.disease
Virology
Vaccination
Infectious Diseases
Immunization
Condylomata Acuminata
Immunology
biology.protein
bacteria
Molecular Medicine
Antibody
Adjuvant
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 18
- Issue :
- 11-12
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....71b715b78210b5324a4b34ae03af5c38