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The Relation Between Adult Weight Gain, Adipocyte Volume, and the Metabolic Profile at Middle Age
- Source :
- The Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Endocrinology and Metabolism 106 (2021) 11, Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447. ENDOCRINE SOC, Journal of Clinical Endocrinology and Metabolism, 106(11), E4438-E4447
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- Context Weight gain during adulthood increases cardiometabolic disease risk, possibly through adipocyte hypertrophy. Objective We aimed to study the specific metabolomic profile of adult weight gain, and to examine its association with adipocyte volume. Methods Nuclear magnetic resonance–based metabolomics were measured in the Netherlands Epidemiology of Obesity (NEO) study (n = 6347, discovery) and Oxford Biobank (n = 6317, replication). Adult weight gain was calculated as the absolute difference between body mass index (BMI) at middle age and recalled BMI at age 20 years. We performed linear regression analyses with both exposures BMI at age 20 years and weight gain, and separately with BMI at middle age in relation to 149 serum metabolomic measures, adjusted for age, sex, and multiple testing. Additionally, subcutaneous abdominal adipocyte biopsies were collected in a subset of the Oxford Biobank (n = 114) to estimate adipocyte volume. Results Mean (SD) weight gain was 4.5 (3.7) kg/m2 in the NEO study and 3.6 (3.7) kg/m2 in the Oxford Biobank. Weight gain, and not BMI at age 20 nor middle age, was associated with concentrations of 7 metabolomic measures after successful replication, which included polyunsaturated fatty acids, small to medium low-density lipoproteins, and total intermediate-density lipoprotein. One SD weight gain was associated with 386 μm3 (95% CI, 143-629) higher median adipocyte volume. Adipocyte volume was associated with lipoprotein particles specific for adult weight gain. Conclusion Adult weight gain is associated with specific metabolomic alterations of which the higher lipoprotein concentrations were likely contributed by larger adipocyte volumes, presumably linking weight gain to cardiometabolic disease.
- Subjects :
- 0301 basic medicine
Male
Aging
Endocrinology, Diabetes and Metabolism
Biopsy
Clinical Biochemistry
030204 cardiovascular system & hematology
Biochemistry
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Adipocyte
Adipocytes
Medicine
Netherlands
chemistry.chemical_classification
weight gain
Middle Aged
metabolomics
metabolic profile
Nutritional Biology
Metabolome
Female
medicine.symptom
AcademicSubjects/MED00250
Polyunsaturated fatty acid
medicine.medical_specialty
Lipoproteins
Abdominal Fat
Context (language use)
body mass index
03 medical and health sciences
Internal medicine
cohort study
Humans
Obesity
Online Only Articles
Clinical Research Articles
adipocyte volume
business.industry
Biochemistry (medical)
Middle age
030104 developmental biology
chemistry
Adipocyte hypertrophy
business
Weight gain
Body mass index
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 19457197 and 0021972X
- Volume :
- 106
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....71c8cba5450bfc64895037acf4140ab2